This study aims to investigate the level of life skills and psychological immunity among university students in the Southern governorates in Palestine. Moreover, it checks the feasibility of predicting psychological immunity in the light of the life skills of students. Further, it explores the relationship between psychosocial skills and innate immunity. Furthermore, it examines the difference between university students based on demographic variables (gender, academic level, specialization. The study sample consists of 1116 male and female students from institution. This survey also uses study tool variables (tools the life skills scale and the psychological immunity scale). The findings demonstrate high level of life skills at 82.12% and a very high rate of psychological immunity 84.43% among the Palestinian University students, psychological immunity in the view of life skills a long with acceptable degree of (57.3%). As a result, there is positive statistically correlation at the level of (0.01) between the degree of each life skills scale besides psychological immunity among the students in the Palestinian universities a long with high and positive correlation coefficient of (0.757). on he one hand, there are no statistically significant differences between life skills, psychological immunity and joint interactions (gender, academic level, specialization).