The study aimed to identify the role of innovative leadership in increasing the efficiency of strategic ambidexterity as a case study of Al-Aqsa University in Gaza Strip - Palestine. This study has been tested through the testing its hypotheses, answering the study questions. The descriptive-analytical approach was used, as a questionnaire of decimal scale was targeted a simple random sample of 199 participants of the faculty members of Al-Aqsa university. The study concluded a set of results; the most important one that innovative leadership is related to increasing the efficiency of strategic ambidexterity, and that there is a statistically significant effect of innovative leadership on strategic ambidexterity. The study recommended to pay much attention to strategic ambidexterity through conducting a training programs and scholarships for faculty members at the university and stimulating innovative leadership and adopting innovative methods.